Early nucleus basalis of Meynert degeneration predicts cognitive decline in Parkinson’s disease
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چکیده
منابع مشابه
Comparative analysis of the nucleus basalis of Meynert among primates.
Long projection axons from the Ch4 cell group of the nucleus basalis of Meynert (nbM) provide cholinergic innervation to the neurons of the cerebral cortex. This cortical cholinergic innervation has been implicated in behavioral and cognitive functions, including learning and memory. Recent evidence revealed differences among primate species in the pattern of cholinergic innervation specific to...
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ADAS-cog 1⁄4 Alzheimer’s disease Assessment Scale, MMSE 1⁄4Mini Mental Status Examination, RWT 1⁄4 Regensburger Wortschatz Test, WAIS 1⁄4 Wechsler Adult Intelligence Scale, WMS 1⁄4 Wechsler Memory Scale, BDI II 1⁄4 Beck’s Depression Inventory (2nd edition), HAMD 1⁄4 Hamilton Depression Rating Scale, FAST 1⁄4 Florida Apraxia Screening Test. a A lower value represents a better outcome. b A higher...
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The population of neurons and the neuronal size in the nucleus basalis of Meynert (nbM) were studied in 20 patients with definite Creutzfeldt-Jakob disease (CJD). When compared with a normal control group, the 20 CJD brains showed a significant loss of neurons and reduction of neuronal size, mainly in the middle level of the nbM and mostly affecting the right side. Since these findings show som...
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We examined the degree of neuronal loss from the nucleus basalis of Meynert (nbM) in two groups of Alzheimer patients differing in the degree of intellectual impairment. Significant cell loss from the nbM was found only in the more severely demented group of patients. Mean cell counts (per 10 mu paraffin section) were compiled separately for the anterior, intermediate and posterior subdivisions...
متن کاملPotential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease
The brain's cholinergic arousal pathways decline in parallel with the brain's executive functions in aging and Alzheimer's Disease. The frontline and currently most effective approach to treating Alzheimer's disease is the administration of cholinesterase inhibitors, which, in a dose dependent manner, improve the symptoms of cognitive decline over the first months of treatment before further de...
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ژورنال
عنوان ژورنال: Brain
سال: 2017
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awx333